abstract |
The invention discloses a parathyroid hormone (PTH) derivative which has an amino acid sequence shown in SEQ ID NO: 1. With glutamic acid as a spacer, epsilon-amino of lysine at the 26-th position is connected with a lipophilic group W which has 12-40 carbon atoms and selectively contains a group capable of carrying negative charges so as to finally obtain the PTH derivative. Compared with PTH, the derivative has longer in vivo half-life period; therefore, the PTH administration frequency can be reduced, and compliance and treatment effect of medicines can be improved. |