http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102399238-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_23f0ca3d8f3c3ae66bef87435fbe1ad7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-165 |
| filingDate | 2011-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_474b8b26dae962b6abb569e3ccf3d995 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cbf4cf2226e70ba8a23f1ca525e4b669 |
| publicationDate | 2013-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102399238-B |
| titleOfInvention | Preparation method for amifostine |
| abstract | The invention discloses a preparation method for amifostine. The preparation method comprises the following steps of: adding concentrated hydrochloric acid dropwise into N-(2-hydroxylethyl)1,3propane diamine serving as a basic raw material and reacting; after the reaction is finished, concentrating, devitrifying and drying to obtain ammonium salt; reacting the obtained ammonium salt with a chlorating agent and a catalyst; after the reaction is finished, performing treatment to obtain chloride, namely 2-(3aminopropyl amino)ethyl dichlorohydrochloride; adding sulfo-sodium phosphate and purified water into a reaction vessel; adding potassium iodide and stirring to form suspension for later use; dissolving the chloride into the purified water to obtain a chloride solution; filling into a constant-pressure titration hopper; adding dropwise into the reaction vessel accommodating the suspension for later use and reacting; and after the reaction is finished, performing treatment to obtain the product amifostine. The amifostine is synthesized by the technical scheme, so yield is high, reaction time is short, cost is low and the preparation method is easy to control and suitable for large-scale production. |
| priorityDate | 2011-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.