http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102391138-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7beaa3e0d121afbb4f783c6ed70a05de |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-08 |
| filingDate | 2011-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63ae10d85bcfe087c6116a8e16ac896e |
| publicationDate | 2014-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102391138-B |
| titleOfInvention | Method for preparing D-valine by using asymmetric transformation method |
| abstract | The invention belongs to the technical field of chiral amino-acid compound preparation, and specifically relates to a method for preparing D-valine by using an asymmetric transformation method. The method is implemented through the following steps of: carrying out asymmetric transformation on a chiral resolution reagent (+)-1-phenyl ethanesulfonic acid and a dl-valine under the catalytic action of a solvent and a catalyst so as to obtain a corresponding target double salt solution; and sequentially carrying out separation, washing and dissociation on the obtained target double salt solution so as to obtain the D-valine, wherein the total yield is more than 90%, the resolution reagent (+)-1-phenyl ethanesulfonic acid can be recycled, and a mother solution also can be reapplied to the next asymmetric transformation process. By using the method provided by the invention, a racemization step in a classical resolution method is saved, the loss of another enantiomers is avoided, the resolution efficiency is improved, the operation is simplified, and an entrained separation phenomenon caused by that the concentration of enantiomers is increased in the classical resolution method is avoided, so that the optical purity (greater than 99% ee) of the D-valine is ensured. The chiral reagent and the mother solution can be recycled, so that the production cost is greatly lowered, therefore, the method provided by the invention is suitable for industrial production processes. |
| priorityDate | 2011-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.