| abstract |
Provided herein are fused imidazolyl compounds and methods of synthesizing and using them. The compounds provided herein are useful in the treatment, prevention and/or management of various conditions, such as neurological and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters such as histamine, acetylcholine, norepinephrine, and dopamine (eg, at synapses). Also provided herein are pharmaceutical formulations comprising the compounds and methods of their use. |