| abstract |
The present invention discloses N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1, Malates of 1-dicarboxamides, including (L)-malate, (D)-malate, (DL)malate and mixtures thereof; and crystalline and amorphous forms of these malates . The present invention also discloses N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane- A pharmaceutical composition of at least one malate salt of 1,1-dicarboxamide; and a method of treating cancer comprising administering N-(4-{[6,7-bis(methyloxy)quinoline -4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide at least one malate salt. |