| abstract |
The invention relates to cyclohexanone-contained mono-carbonyl analogues of curcumin and usage thereof. When compared with curcumin which is an excellent lead compound and has various pharmacological activities, the analogues have more stable mono-carbonyl intermediate junction chain structure, cyclohexanone serves as the joint chain, and substituent on benzene rings of the analogues has specificcombination. Pharmaceutically acceptable salts of the analogues, pharmaceutical preparations contained the analogues and pharmaceutical usages of the analogues are further provided. Correlational researches of the cyclohexanone-contained mono-carbonyl analogues of curcumin show that the analogues can be used for treatment of inflammation and tumors. |