http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102372707-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2010-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102372707-B |
| titleOfInvention | The synthetic method of 6-methyl-4-bromo-1,6-pyrrolin [2,3-c] pyridin-7-one |
| abstract | The present invention relates to the synthetic method of a kind of important medicine intermediate 6-methyl-4-bromo-1,6-pyrrolin [2,3-c] pyridin-7-one.The reaction scheme mainly solving existing synthetic route shortage and existence is long, and aftertreatment is complicated, expensive starting materials, the technical problems such as suitability is wideless.Technical scheme of the present invention: 6-methyl-4-bromo-1,6-pyrrolin [2,3-c] synthetic method of pyridin-7-one, comprise the following steps: the first step reaction for raw material, is obtained by reacting the bromo-pyridine 2 of 3-nitro-2-methoxyl group-5-with the bromo-pyridine of the chloro-5-of 3-nitro-2-in methyl alcohol with sodium methylate; Second step reacts, and under compound 2 cold condition, generates 7-methoxyl group-4-bromo-1-hydrogen pyrroles [2,3-c] pyridine 3 in a solvent with form reagent react; Three-step reaction, compound 3 is with generating 4-bromo-1,6-pyrrolin [2,3-c] pyridin-7-one 4 after demethylation reagent demethylation; Four-step reaction, compound 4 and methylating reagent react and generate 6-methyl-4-bromo-1,6-pyrrolin [2,3-c] pyridin-7-one under alkalizing agent exists. |
| priorityDate | 2010-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.