| abstract |
A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, wherein n is 0 or an integer selected from 1-4; R is cycloalkyl, aryl, heteroaryl or heterocyclyl, and each group is optionally is optionally substituted by 1-5 substituents independently selected from C 1 -C 6 alkyl, C 1 -C 4 haloalkyl, benzyl, -OR 4 and/or halogen; and R 2 , R 3 , R 4 and n are defined by this application. Also disclosed are methods of using such compounds as selective agonists of the G protein coupled receptor S1P1 , as well as pharmaceutical compositions comprising such compounds. These compounds are useful in many therapeutic areas for treating, preventing or slowing the progression of diseases or disorders, such as autoimmune and vascular diseases. |