| abstract |
The present invention relates to for the local application of botulinum toxin and the compositions of transdermal delivery and method, particularly relate to the compositions of the local delivery for botulinum toxin (comprising the derivant of botulinum toxin), it comprises botulinum toxin and carrier, described carrier comprises main polymer chain, and described main chain comprises the long-chain polypeptide of positively charged branch or " usefulness " group with attachment or non-peptidyl polymer.The present invention also relates to such method, the method by giving skin or the epithelium local application of experimenter together with carrier by the botulinum toxin of effective dose, reduce the paralysis of the disease, particularly subdermal muscle of muscular paralysis and available botulinum toxin treatments, and the paralysis of facial muscle the most in particular.Also illustrate the test kit for using. |