http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102351783-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-74 |
| filingDate | 2011-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102351783-B |
| titleOfInvention | The synthetic method of 1-benzyl-3-piperidone hydrochloride |
| abstract | The invention discloses the synthetic method of 1-benzyl-3-piperidone hydrochloride, comprise the steps: that 3-pyridone adds in organic solvent by (1), 100-110 DEG C of backflow, drip halogenation benzyl, continue back flow reaction 2-4 hour, obtain product A; (2) product A is added in alcohol organic solvent, under ice bath, after adding sodium borohydride, recover room temperature stirring reaction 10-15 hour, then add shrend and to go out reaction solution, remove alcohol organic solvent, adding strong acid adjusts PH to be 1-2, extraction agent extraction retains aqueous phase, adjusts PH to 13-14, obtain product B with alkaline solution; (3) be ketone group by polite oxidizing reaction by the hydroxyl oxidize in product B, washing, dry organic phase, filters, concentrated, add hydrochloric ethyl acetate solution until PH is 1-2, stir, cooling, after solid is separated out completely, filter, dry to obtain 1-benzyl-3-piperidone hydrochloride of the present invention.Of the present invention with low cost, operational safety. |
| priorityDate | 2011-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.