http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102351734-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d5fe069ff37b62982738df2edf2fd97 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2011-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b010bd63f855830cbc90851e14251fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a385c4fcbeb8928658dae351be90f19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35bf777a7d86631470e112ecd5576da4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_017023608f90bc079f046cb6e428fa3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ef84b3b6cfbaa9e643cb29f1cf5fb48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3e5bf0185e8071f03c7849656bc1264 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c18ea4ee138c55004c925933361bbe8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32569f74bd1ef80c0fa7bababbba47a9 |
| publicationDate | 2014-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102351734-B |
| titleOfInvention | Preparation method for aliskiren |
| abstract | The invention discloses a preparation method for aliskiren. The preparation method comprises the following steps of: preparing a compound (I) from (3S, 5S, 1'S, 3'S)-5-(1'-azido-3'-hydroxymethyl-4'-methyl-amyl)-3-isopropyl-dihydrofuran-2-ketone through catalytic oxidation; performing addition with 4-methoxyl-3-(3-methoxyl propoxy)-bromobenzene under the action of a metal reagent to obtain a compound (II); then performing catalytic hydrogenation and amino group protection to obtain a lactone compound (III), serving an important intermediate of the aliskiren; and finally condensing with 3-amino-2,2-methacrylamide and removing an amino protecting group to obtain the aliskiren. Compared with the prior art, the preparation method has the beneficial effects of cheap and readily available raw materials, short reaction route, easiness and convenience in operation, no special requirement on equipment, high yield, low cost and small environmental protection pressure, is suitable for commercial production and has a higher industrial application value. |
| priorityDate | 2011-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 172.