abstract |
The present invention relates to an improved method for synthesizing meropenem trihydrate [(1R,5S,6S)-3-[((3'S,5'S)-5'-(dimethylaminocarbozyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-4-methyl-7-oxygen-1-azabicyclo[3.2.0]heptyl-2-em-3-carboxylic acid, trihydrate], which is a novel carbapenem antibiotic. |