http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102348683-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_241c3d4e236532a2e822eb39f56b1be9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-405 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-405 |
| filingDate | 2010-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dd1f92c37014cdb87feaf79ddb186f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9abfc629e514d17941311e3cea696dae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d74041d53229604f8a8df62fac3951e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44c0970828c1ceeaae1a5908b43b914b |
| publicationDate | 2012-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102348683-A |
| titleOfInvention | Prophylactic or therapeutic agent for optic nerve damage containing 4,6-dichloro-1H-indole-2-carboxylic acid derivative or salt thereof as active ingredient |
| abstract | The discovery of a compound useful as a preventive or therapeutic agent for optic nerve damage, an inhibitor of retinal nerve cell death, or an agent for restoring the expression level of neurofilament light chains is a subject of great interest, especially the discovery of a compound that exhibits Compounds of this pharmacological effect are the subject of great interest. 4,6-Dichloro-1H-indole-2-carboxylic acid derivatives or salts thereof, when administered orally to NMDA-induced rat retinal injury models, significantly inhibited the number of cells in the retinal nerve cell layer In addition, when intravitreal administration (topical administration to the eye) was administered to the same model, the reduction in expression of neurofilament light chains in the retina was restored. Therefore, it is useful as a preventive or therapeutic agent for optic nerve damage, an inhibitor of retinal nerve cell death, or an agent for restoring the expression level of neurofilament light chain. |
| priorityDate | 2009-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.