| abstract |
The present invention relates to benzothiazine derivatives having the ability to inhibit 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) not only at the enzymatic level but also at the cellular level. The compounds of the invention conform to the general formula (I). Notably, wherein R 1 represents hydrogen or OR 1 represents an ester or ether. R 2 represents naphthyl or 1,2,3,4-tetralin or biphenyl or phenylpyridine or substituted phenyl. R 3 represents methyl or ethyl. R4 and R'4 represent hydrogen . |