http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102336729-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f90184aa49d983ea9815377382fb04b3 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C55-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 |
| filingDate | 2011-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ccb9512d719e5662ad6ec2e2c174ab1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97002b7a137aadfc7a680c63039798f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a3579355c0de20d8f51996afaa9a1cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09348e9a9f39c90ea581a276c11a77fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_735e204593d5e65bf4258b5113dff85c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa95fa65ddbb9cdd0691e50d336ec402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed78e26bd0cc75ddba704c9b336a9e7d |
| publicationDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102336729-B |
| titleOfInvention | Preparation method for escitalopram oxalate |
| abstract | The invention discloses a preparation method for escitalopram oxalate, which is characterized in that D-toluoyl tartrate of S-diol is dissolved into water, and sodium hydroxide is used for neutralization to obtain free S-diol; then, the temperature is controlled to be 0 to 10 DEG C, paratoluensulfonyl chloride is added, then, inorganic alkaline solution is dripped, and the ring closure reaction is carried out after the reaction for 2 to 4 hours; after the reaction is completed, the pH value is regulated to 12 to 13, and then, the extraction, the water washing and the liquid separation are carried out; and after oxalic acid is added for salt forming, the temperature reduction, the filtering and the drying are carried out, and products are obtained. In the ring closure reaction, water is adopted as solvents, the condition is mild, the environment is friendly, byproducts of each step of reaction in the synthesis method are few, the yield is high, in addition, products in each step of reaction are easy to separate and purity, raw materials used in the synthesis method are easy to obtain, the operation is simple, and the industrial production is easy. |
| priorityDate | 2011-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.