http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102335134-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b946f8a160a77d9f664816a704364d83 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 2011-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee74484731c302eb8043a6e924505297 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aaedc84e7680c1001226c81f5b5e595c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fcd2f59153bd5529cc940729dd8f94a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bececb42268e44fb0c846684e7e340a0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c66b8f1d004d6e3da562af4848b21aa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00d1d74db14c6accc821d69b1185c93f |
| publicationDate | 2014-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102335134-B |
| titleOfInvention | Clevidipine butyrate liquid liposome preparation |
| abstract | The invention discloses a clevidipine butyrate liposome preparation and a preparation method thereof. The preparation includes 0.05wt%(wt%)-0.1%(wt%) of clevidipine butyrate, 40%(wt%) -70%(wt%) of phosphatidylcholine, 10%(wt%)-40%(wt%) of phosphatidyl glycerol, 10%(wt%)-30%(wt%) of sterol, and 0.55%(wt%)-3.3%(wt%) of stabilizer. The stabilizer contains a component A and a component B, wherein the component A is selected from one or more of oleic acid, sodium oleate, linoleic acid and sodium linoleate; and the component B is selected from one or more of vitamin E, coenzyme Q10, propyl gallate and ascorbyl palmitate. The liposome prepared by the method is in the form of liquid, and can be stored for a long time, therefore not only the potential safety hazard due to use of middle-chain and long-chain triglyceride in the traditional clevidipine butyrate emulsion is thoroughly solved, but also the freeze-drying operation in the traditional liposome preparation is omitted and the production cost is reduced; moreover, the liposome preparation is convenient for clinical application, overcomes the defect of uneven quality of redissolved freeze-drying liposome preparation and is beneficial to increase of the compliance and the medication safety of a patient. |
| priorityDate | 2011-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.