http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102321046-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24c6c2c562cbff40a65d618fb81fcb53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-42 |
| filingDate | 2011-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_293e23c74b5e1bf73112f011cf265625 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8cd3038ac8c7d49323deeac7b926a4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_474eac33321b2ae530a199a7dacbcfe1 |
| publicationDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102321046-B |
| titleOfInvention | Method for preparing 2-(N-alkyl)aminothiazole and 2-(N-alkyl) aminooxazole derivative by N-alkylation reaction |
| abstract | The invention provides a new method for preparing 2-(N-alkyl)aminothiazole and a 2-(N-alkyl) aminooxazole derivative. The method comprises the following steps: adding 2-aminothiazole or a 2-aminooxazole derivative, a catalyst, alkali, alcohol and an organic solvent (or organic solvent-free) in a reactor under the condition of nitrogen protection or air to react for hours at the temperature of 100-150 DEG C; evaporating to remove surplus solvents or reactants; and carrying out column separation so as to obtain a target compound. The preparation method provided by the invention has the following four obvious advantages that 1) nearly-nontoxic alcohol is used as an alkylation reagent; 2) in the process of reaction, water is just generated as a byproduct, thus no environmental hazards are generated; 3) the reaction has high atom economy; and 4) the reaction system is not merely limited to benzyl alcohol, and has high reaction activity on fatty alcohol, secondary alcohol and the like, moreover, the reaction system is not merely limited to 2-aminobenzothiazole derivatives, and has high reaction activity on non-benzo 2-aminothiazole and 2-aminooxazole, thus the range of substrates is greatly expanded in the reaction. The new method in the invention has wide development prospect. |
| priorityDate | 2011-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 135.