| abstract |
The present invention relates to enzyme inhibitors of phosphodiesterase 4 (PDE4). More particularly, the present invention relates to compounds of -phenyl-2-pyridylalkanol derivatives, processes for their preparation, compositions comprising them, combinations of formula (I) and their therapeutic use, wherein: n is 0 or 1; R1 and R2 may be the same or different, and are selected from: - linear or branched C 1 -C 6 alkyl; OR3, wherein R3 is optionally substituted by one or more C 3 -C 7 cycloalkyl Straight chain or branched C 1 -C 6 alkyl ; and HNSO 2 R4, wherein R4 is C 1 -C 4 alkyl optionally substituted by one or more halogen atoms or C 1 -C 4 alkyl, wherein R1 and at least one of R2 is HNSO2R4 , the other variables are as defined in the claims. |