http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102304082-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3d7e466c44c7b54e2a48e4bf62665ef |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 |
| filingDate | 2011-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54f77225cf4069bacdc2f8bee4fa9b1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aac9c0d3b9457b71a6f5e29e2015f272 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_518b36266fcd9856f253b06d7f6a1fc2 |
| publicationDate | 2013-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102304082-B |
| titleOfInvention | Synthesis method of 2-chloro-4-(piperidylmethyl)pyridine |
| abstract | The invention relates to a synthesis method of 2-chloro-4-(piperidylmethyl)pyridine, belonging to the field of medicine synthesis. The method comprises the following steps: dropwisely adding a nitrite water solution into acid and 2-amino-4-methylpyridine to react, thereby obtaining a white solid product; adding POCl3 into the white solid to obtain a compound 2-chloro-4-methylpyridine; dropwisely adding SO2Cl2 into the compound 2-chloro-4-methylpyridine while adding a free-radical initiator batch by batch, and distilling under reduced pressure to obtain a compound 2-chloro-4-chloromethylpyridine; and condensing the 2-chloro-4-chloromethylpyridine and piperidine to obtain the 2-chloro-4-(piperidylmethyl)pyridine. Compared with the traditional synthesis method of 2-chloro-4-(piperidylmethyl)pyridine, the synthesis method provided by the invention has the advantages of simpler steps (only three steps) and lower cost of raw materials, and the total yield is higher than 32%. Generally, the invention can greatly lower the synthesis cost of lafutidine. |
| priorityDate | 2011-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.