http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102293736-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_daa5a466c918d96992db36ad5eb52436 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 |
| filingDate | 2011-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a82d7220302e551dfdf9b667e304aea4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e99af937df3fbc3a8d6b777edb5d7286 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92fe6d1453c1938b4e48c087a4a4f300 |
| publicationDate | 2013-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102293736-B |
| titleOfInvention | Preparation process of taxol-polymer medicine-carrying micelles |
| abstract | The invention relates to a preparation process of taxol-polymer medicine-carrying micelles and belongs to the technical field of preparation of medicines. The preparation process comprises the following steps of: 1) preparing mixed solution of taxol and a carrier material; 2) preparing a dry lipid film and removing the residual organic solvent; 3) adding a proper amount of 0.9 percent sodium chloride solution into warm water bath, placing into a constant-temperature water bath oscillator to oscillate at constant temperature for 0.5 to 5 hours, wherein the frequency is 50 to 250 times per minute; and 4) cooling material solution obtained in the step 3) and performing membrane filtration to prepare the taxol-polymer medicine-carrying micelles, wherein the carrier material is polyethylene glycol 2000-distearoyl phosphatidyl ethanolamine (PEG2000-DSPE) or a mixture of the PEG2000-DSPE and DSPE. By the process of the invention, a new hydration method is provided, so that the properties of the micelles can be improved or remain unchanged. The PEG2000-DSPE is replaced by the cheap DSPE with considerable quantity (such as 70 percent), so the measured average grain size is still far less than the minimum average grain size of the taxol PEG2000-DSPE polymer micelle particles prepared by the traditional method. |
| priorityDate | 2011-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.