http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102286092-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_737f26f8a855ec04924283dd1e7e2b27 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-042 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 |
| filingDate | 2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cbb0b4b7d5f88ab59b8141df64afc70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35ac4cd32172a816cb07f62ac3d362c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_889221ddbd84c2db7872205e3e15a293 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f457de2e0ee010c2bf5ea40b7f6d71a |
| publicationDate | 2014-01-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102286092-B |
| titleOfInvention | Solid-phase synthesis method of liraglutide |
| abstract | The invention provides a solid-phase synthesis method of liraglutide, comprising the following steps: (A) coupling a resin solid-phase carrier and glycine (Fmoc-Gly-OH) with N-end Fmoc protection in the existence of an activating agent system to obtain Fmoc-Gly-resin; (B) sequentially coupling amino acids with N-end Fmoc protection and side chain protection according to a liraglutide main chain peptide sequence by using the solid-phase synthesis method, wherein lysine adopts Fmoc-Lys(Alloc)-OH; (C) removing a protective group Alloc of a side chain of the lysine; (D) coupling Palmitoyl-Glu-OtBu to the side chain of the lysine by using the solid-phase synthesis method; (E) splitting and removing the protective group and the resin to obtain crude peptide of the liraglutide; and (F) purifying and freeze-drying to obtain the liraglutide. The solid-phase synthesis method provided by the invention has the advantages of simplicity in operation, short synthesis period, low production cost, reduction of waste liquid, easiness in aftertreatment, less byproducts and high yield of products and is beneficial for large-scale production of the liraglutide. |
| priorityDate | 2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 110.