http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102286044-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3c5680ea321e20b8f39a618fa7d6571f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 |
| filingDate | 2011-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa8bd3e27712fa5c62677d48e744b3ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7089538ac2d0d54f21808b48c3c9c0c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a62e86fad438e3b66d24c081174b4b5 |
| publicationDate | 2014-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102286044-B |
| titleOfInvention | Preparation method of natamycin laminar crystal |
| abstract | The invention relates to a preparation method of a natamycin laminar crystal, and the preparation method comprises the following steps: (1) adding natamycin mycelium into a methanol and water mixed liquid, wherein the volume ratio of methanol to water is (60-90):(40-10); (2) adjusting the pH value to 10-12 with a basic substance; (3) carrying out liquid-solid separation and collecting filtrate to obtain a natamycin extract; (4) concentrating the extract until the content of natamycin is 18-26 mg/mL, and flocculating to remove insoluble substances to obtain a natamycin fine extract; (5) acidifying the natamycin fine extract by two stages: firstly dripping acid slowly until the pH value decreases to 8-9, then stirring for more than 1 hour, then slowly dripping the acid until the pH value decreases to 6-7, and then stirring for more than 3 hours to obtain a crystallization liquid of the laminar natamycin crystal; and (6) carrying out liquid-solid separation and drying in vacuum to obtain the laminar natamycin crystal. By adoption of the preparation method provided by the invention, the uniform natamycin laminar crystal can be prepared, the subsequent crystal washing and drying difficulties are reduced, and the crystal filtering and drying time is shortened. |
| priorityDate | 2011-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.