http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102285914-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6661683fc6f71608901ad301d7d1a299 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e0b5193c00731d77fb5ce1ed7ba178e6 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 |
| filingDate | 2010-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23557ffa392baf11009e6de442f2d7b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d3a1b9f18d57e6c848566aeb6dbc7db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e2e1524d34218f18c9d8bed0bfa4fc8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_865d180dd524be6cfb3be2e20d4a21a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef1d3d3679a66f7b81b82f83756fc721 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0485c9b83bfbcd43caf8e0a1d9002b8 |
| publicationDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102285914-B |
| titleOfInvention | Synthesis method of 2-(1-methyl-6-carboxy-1,6-dihydropyridine)-acetic acid |
| abstract | The invention relates to a synthesis method of 2-(1-methyl-6-carboxy-1,6-dihydropyridine)-acetic acid, wherein problems that the current synthesis route is lacked, the reaction route is long, the post-treatment is complex, the amplification is difficult, the applicability is not wide and the like are solved by a fast efficient acetic acid group introducing method mainly. The synthesis method comprises the following steps of: reacting 6- chloro-1-hydrogen-pyridine-2-ketone 1 with a methylating reagent in the presence of an alkalization reagent to obtain 1-methyl-6-chloro-1-hydrogen-pyridine-2-ketone 2; reacting the compound 2 with acetonitrile in a solvent in the presence of the alkalization reagent, n-butyl lithium, at low temperature to generate 2-(1- methyl-6-carboxy-1,6-dihydropyridine)-acetonitrile 3; and hydrolyzing the compound 3 under the acidic condition to obtain the final product, 2-(1- methyl-6-carboxy-1,6-dihydropyridine)-acetic acid 4. A large amount of 2-(1- methyl-6-carboxy-1,6-dihydropyridine)-acetic acid can be quickly and conveniently prepared through the synthesis route disclosed by the invention. |
| priorityDate | 2010-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.