http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102283812-B

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filingDate 2010-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102283812-B
titleOfInvention Nanoparticle preparation for treating brain diseases
abstract The invention discloses a nanoparticle preparation for treating brain diseases. The nanoparticle preparation comprises the following raw materials in part by weight: 10 to 250mg of geniposide or total iridoid glycoside of cape jasmine fruit serving as a medicament carried by the nanoparticle preparation; 50 to 300mg of polylactic acid-glycolic acid copolymer serving as a carrier of the nanoparticle preparation; and 200 to 500mg of polyvinyl alcohol and 1 to 30mg of tween-80 or hydrogenated castor oil serving as emulsifiers of the nanoparticle preparation. The invention also discloses the nanoparticle preparation, which is modified by chitosan, wherein the geniposide or total iridoid glycoside of cape jasmine fruit serves as a carried medicament of the nanoparticle preparation. The nanoparticle preparation is prepared by a multiple emulsion-solvent evaporation method. The preparation is administrated through nasal cavities, so the concentration of the geniposide or total iridoid glycoside of cape jasmine fruit in brain tissues is effectively increased. Compared with preparations prepared from the geniposide or total iridoid glycoside of cape jasmine fruit, which are administrated through gastrointestinal tracts, intramuscular injection and the like, the nanoparticle preparation has the advantages of small dosage and high patient compliance.
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