abstract |
Disclosed are compounds of Formula (1), in which A<1>, Z<1>, Z<1A>, Z<2>, Z<2A>, L<1> and Z<3> are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating diseases during which anti-apoptotic Bcl-2 protein is expressed. |