| abstract |
The invention belongs to the field of medicine, in particular to benzothiazinethione derivatives and their preparation methods and applications. The technical problem to be solved by the present invention is to provide a new class of benzothiazinethione derivatives, the structure of which is shown in formula I. The benzothiazinethione derivatives of the present invention are novel compounds obtained on the basis of a large number of screenings. compound, the experimental results show that the benzothiazinethione derivatives shown in formula I have obvious inhibitory effect on Mycobacterium tuberculosis, and the effect is equivalent to or even better than that of isoniazid (MIC 90 =0.8μM), and has anti-tuberculosis properties. Mycobacterium activity provides a new option for the development and application of anti-tuberculosis drugs. |