http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102276592-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_caacf483b6be9ae2d2677103a70559db |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-36 |
| filingDate | 2011-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e33cffe075b224777497c8a3439643b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d2f5a49410dd948242de8d5122d6fc9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf7cbb4430e361a9687365e0efdb1a41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9fb622247eeaa62b9411b5fd5e90e1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e368667c6a3885a485435373b41c90ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41566703a8c2210b3c98fced42b6b6b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0954fb28c0404c4f1a751f2528ced65 |
| publicationDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102276592-B |
| titleOfInvention | Related substance of olanzapine and preparation method and analytical method thereof |
| abstract | The invention discloses a related substance of olanzapine and a preparation method and an analytical method thereof. A structural formula of the related substance of the olanzapine is shown in the specification. The preparation method of the related substance of olanzapine comprises the following steps of: concentrating ethanol recrystallization mother liquor of the olanzapine, and separating through silica gel column chromatography to obtain the related substance of the olanzapine. In addition, the invention provides high performance liquid chromatography for the related substance of the olanzapine. A reversed phase C18 chromatographic column is adopted; the detection wavelength is 220 to 280nm; the flow velocity is 0.5 to 1.0ml/min; the column temperature is 25 to 30 DEG C; and methanoland an aqueous phase obtained by regulating the pH value of 0.3 percent triethylamine to 3.50 to 4.20 by using glacial acetic acid are taken as a mobile phase for gradient elution. The related substance of the olanzapine and other seven related substances can be synchronously analyzed. Separating degrees of any two compounds are more than 2.0, tailing factors are 1.0 to 1.5, numbers of plates aremore than 5,000, relative standard deviations (RSD) are less than 2.0 percent, and the invention is applicable to the preparation process for the olanzapine and the quality control of products, and meets the requirements of pharmacopeias at home and abroad. |
| priorityDate | 2011-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.