http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102276492-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102276492-A |
| titleOfInvention | Agomelatine intermediate and preparation method thereof |
| abstract | The invention relates to the technical field of an intermediate compound for preparing agomelatine and a preparation method thereof. The said agomelatine intermediate of the present invention is the compound A of the following formula. The present invention provides two new intermediate compounds. The preparation of agomelatine with the new intermediate compounds is simple in operation, good in controllability and high in purity, and there is no complicated operation such as rectification and column chromatography separation in the post-treatment. Very suitable for industrial production. Simultaneously, the preparation method of two new intermediates of the present invention itself is simple, and yield is high, with the most commonly used 7-methoxytetralone as starting material, only one-step reaction is available, and then one-step reaction is just The target product agomelatine can be obtained, which greatly shortens the reaction steps of the existing technology for preparing agomelatine, improves the reaction yield, and eliminates the technical problem of difficult purification in the traditional route, and the general yield is stable at 70%. above. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102452951-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014056421-A1 |
| priorityDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.