http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102274211-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-00 |
| filingDate | 2011-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102274211-A |
| titleOfInvention | New uses of coumarin compounds |
| abstract | The invention discloses a new application of coumarin compounds. The application is the application of the coumarin compound represented by the formula (I) in the preparation of cholinesterase inhibitors and in the preparation of products for preventing and/or treating Alzheimer's disease. In formula I, R 1 and R 2 satisfy the following 1) and 2): 1) R 1 is H, and R 2 is selected from any one of the following groups: acetyl, propionyl, 4-bromobenzoyl , 4-nitrobenzoyl and 3-nitrobenzoyl; 2) R 1 is propionyl or butyryl, R 2 is H. The results of the in vitro AChE activity inhibition test showed that the compound of formula I had better inhibitory effect on AChE, and compound No. 3 had the strongest inhibitory effect, with an IC 50 value of 15.39 μg/ml. (Formula I) |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111848565-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111848565-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102775374-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108586418-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108586418-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102775374-A |
| priorityDate | 2011-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.