http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102268003-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7641d8ec4b289baa8268f4936e0e4635 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 |
| filingDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d109f4c495d9316866bdf5e6d7bf844f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce989168e8e67f4c14d7818fd8e8cb85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0666fe875444499e96fab1d78f9b3323 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_403f2d0354d529b40f293f6b74d8e04e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c96fa5d3383b7a479d7eba4fe4ac1c56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e25bf74e3c7129de35e36e858f8f8ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb2ac6fb38703569ab76b6ca778e7ea8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6225fc56c3a5e5c0d49f4c7fc5aab346 |
| publicationDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102268003-B |
| titleOfInvention | Unsymmetrical poly-substituted porphyrin gold (III) type anticancer compound and preparation method thereof |
| abstract | The invention discloses an unsymmetrical poly-substituted porphyrin gold (III) type anticancer compound and a preparation method thereof, belonging to the technical field of preparation of medicaments. The preparation method comprises the following steps of: making unsymmetrical poly-substituted porphyrin serving as a ligand react with potassium chloroaurate in an acetic acid system; and performing ion exchange through lithium chloride to obtain the anticancer compound. In the preparation method, different high-polarity radicals are introduced into a porphyrin ring, so that the symmetrical characteristic of molecules is improved, the targeting effect of a poly-substituted tetraphenyl chloride porphyrin gold compound on cancer cells is enhanced, and the dissolving capacity of the compound in water can be facilitated. The compound synthesized with the method has a remarkable inhibiting effect on SGC-7901 and SMMC-7721 tumor cells in vitro and is superior to cis-platinum serving as a positive control medicament, the highest inhibiting rates of 4c and 4a are higher than a pilot compound G0, the IC50 of 4a is less than G0, and higher targeting selectivity is shown. The unsymmetrical poly-substituted porphyrin gold (III) type anticancer compound prepared with the method has high anti-cancer activity, small toxic or side effect and simple, convenient and practicable preparation process, and is suitable for industrial production. |
| priorityDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.