http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102267995-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 |
| filingDate | 2010-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102267995-A |
| titleOfInvention | A kind of method for preparing diaza spiro compound |
| abstract | The invention belongs to the technical field of drug synthesis. In order to solve the reactions involved in the preparation of diazaspiro compounds in the prior art, there are disadvantages such as requiring some relatively expensive reagents and requiring low temperature for operation. The invention provides a method for preparing diazaspirocyclic compounds. The method of the spiro compound, the diaza spiro compound has the structure of formula I or formula VI, the method uses the compound formula V as the initial raw material, comprising: a, removing the No. 1 position in the compound formula V with a proton-removing reagent and then carry out alkylation reaction with the saturated chain alkane formula III with halogenation at both ends to form the first intermediate product formula II; b, replace the carbon at the 2nd position in the first intermediate product formula II with an azide reagent On the halogen X 2 , form the second intermediate product formula IV; c, carry out the reduction ring closure reaction on the second intermediate product formula IV, and form the diaza spiro compound formula I; d, the diaza spiro compound formula I Reduction is carried out to obtain the diazaspiro compound formula VI. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11427585-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019527233-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11530223-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106831774-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190033595-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11299495-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11512051-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11578072-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106939001-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102465758-B1 |
| priorityDate | 2010-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.