http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102250203-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6077d9bd8b6ee0093203fdc84b99bd6c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2010-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91a82577ba8c91d17ae8fbbae02e0cf9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_858ade68ac776ac8a5a4f4a48b1fcbea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4e3c1816d41debf30bf478a56fa76a0 |
| publicationDate | 2014-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102250203-B |
| titleOfInvention | Beta-carboline aminoacid benzyl ester, preparation method and application thereof |
| abstract | The invention relates to a beta-carboline aminoacid benzyl ester, a preparation method and application thereof. According to the invention, L-tryptophan and formaldehyde are treated with Pictet-Spengler condensation under catalysis of dilute sulphuric acid to obtain a series of intermediates; and the intermediates are coupled with a plurality of aminoacid benzyl esters to obtain 2-[tetrahydro-beta-carbolino(2,2-dimethyl-imidazole-4-ketone-3-base)]-4-(methyl propyl)- valeryl aminoacid benzyl ester. The method of the invention is simply operated; raw materials are easily available; and the obtained derivative has excellent antitumor activity in vitro and in vivo. Therefore, the invention discloses 18 varieties of novel 2-[tetrahydro-beta-carbolino(2,2-dimethyl-imidazole-4-ketone-3-base)]-4-(methyl propyl)- valeryl aminoacid benzyl esters to be used as future clinic antitumor drugs. |
| priorityDate | 2010-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.