http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102250096-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D477-20 |
| filingDate | 2011-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102250096-B |
| titleOfInvention | A kind of preparation method of meropenem |
| abstract | A kind of preparation method of meropenem, (1R is added respectively in reaction flask, 5R, 6S)-6-[(1R)-1-hydroxyl]-1-methyl-2-hexichol phosphinylidyne oxygen-carbon mould-2-alkene-3-carboxy acid mutual-nitro carbobenzoxy, (2R, 4S)-4-sulfydryl-2-dimethylin formyl radical-1-is to nitrobenzyl carbonyl pyrrolidine alkane and basic quaternary ammonium salt, stirring reaction, follow the tracks of with TLC, after reaction terminates, adding weight is 5%Pd/C catalyzer, pass into hydrogen reducing, follow the tracks of with TLC, after reaction terminates, extract with toluene, separate organic layer, dry, concentrated, solid product is obtained with Virahol crystallization.Compared with prior art, its advantage is in reaction process in the present invention, employs quaternary amine alkali catalyzer, and homogeneous catalysis one pot reaction technology, simplifies technological operation, environmentally safe. |
| priorityDate | 2011-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.