| abstract |
The invention relates to a preparation method of a key intermediate of a medicine benazepril hydrochloride, that is, 3-[(1-(1S)-phenylethyl) amino]-2,3,4,5-tetrahydro-2-oxo-1H-(3S)-benzazepine. 3-bromo benzo caprolactam and (S)-1-phenylethylamine are used as raw materials; an object product is obtained by amination and a solvent-free configuration transformation reaction; the preparation method has low production cost and simple operations, and has industrial production value. |