http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102247361-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7826e82a59639f553bfb024dfb2a0ea5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f534d378a6abfac8b222f85bfcc5ed3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a13e8fbb3d70a545a97f72a35feb295c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3cf98da98339f659742b99564bc9041 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b3c6c78d6d9d4c2414ca4bfab69a50a |
| publicationDate | 2015-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102247361-B |
| titleOfInvention | Application of 5-nitro-1H-indazol-3-carbonitrile to medicament preparation |
| abstract | The invention discloses application of a compound 5-nitro-1H-indazol-3-carbonitrile shown as formula (I) or physiologically acceptable derivatives thereof to medicament preparation. The compound has effects of inhibiting an Rho kinase activity, raising nitric oxide synthase level to promote nitric oxide generation, blocking calcium channel, opening potassium ion channel, and relaxing and protecting blood vessels, and pharmacological effect of reducing blood pressure, and can be used in preparation of medicaments for controlling vascular diseases caused by abnormal heightening of blood vessel tension force, such as hypertension, atherosclerotic, cerebral vasospasm, coronarospasm, myocardial infarction and heart failure or the like. In addition, the medicament has advantages of low toxicity and simple synthesis process. |
| priorityDate | 2010-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.