http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102241648-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 |
| filingDate | 2011-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102241648-B |
| titleOfInvention | Anti-multidrug resistance taxane derivatives and its preparation method and application |
| abstract | The present invention relates to class taxane derivatives with structure formula (I) and its preparation method and application, wherein, R 1 Represent C (O) OR 6 , C (O) Ar, C (O) CH=CR 7 R 8 , such as: C (O) CH=CF 2 , C (O) CH=C (CH 3 ) 2 , C (O) CH=CHCH 3 , C (O) CH=CHCF 3 Deng；R 2 Represent Ar, alkyl, CH=CR 7 R 8 , such as: CH=CF 2 , CH=C (CH 3 ) 2 、‑CH 2 CH(CH 3 ) 2 Deng；R 3 Represent hydrogen atom, alkyl, alkoxyl, halogen, cyano group, azido, fluorine replacement alkyl, fluorine substituted alkoxy etc., such as: methyl, chlorine atom, fluorine atom, trifluoromethyl, trifluoromethoxy etc.；R 4 Represent hydrogen atom, C (O) R 9 Maybe can increase water miscible hydroxyl substituent etc.；R 5 Represent hydrogen atom, silicon ether, ester group and maybe can increase water miscible hydroxyl substituent；R 6 Represent C 3 ～C 10 The alkyl of straight or branched；R 7 、R 8 Represent identical or different C 1 ～C 10 Straight chain or with the alkyl of side chain, cycloalkyl, halogen, the C of halogen substiuted 1 ～C 10 Straight chain or the alkyl or cycloalkyl with side chain；R 9 Represent C 1 ～C 10 Straight chain or with the alkyl or cycloalkyl of side chain, aryl.This compounds majority can suppress the growth of tumor cell effectively, can be used for treating the multidrug resistance of tumor of high expressed P glycoprotein. |
| priorityDate | 2011-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 176.