| abstract |
The present invention relates to an acrylamide compound of formula I or its isomer, pharmaceutically acceptable salt and solvate, including the compound or its isomer, pharmaceutically acceptable salt and solvate, and pharmaceutically acceptable carrier, excipient Formulation or diluent composition, and the use of said compound or composition for preventing and/or treating diseases or symptoms related to cardiomyocyte apoptosis, including but not limited to (i) starvation myocardial atrophy, (ii) myocarditis, (iii) heart failure, (iv) treatment or alleviation of myocardial injury caused by essential hypertension, (v) treatment or alleviation of myocardial injury caused by early acute myocardial infarction, (vi) treatment or alleviation of acute myocardial infarction Myocardial injury caused by infarct reperfusion, (vii) treatment or alleviation of cardiomyocyte lesion caused by heart transplantation, (viii) treatment or alleviation of dysplastic cardiomyopathy; or cardiomyocyte apoptosis caused by hypoxia, or improvement of cardiovascular system sclerosis the use of. |