| abstract |
The invention discloses a method for preparing an aromatic cross-coupled compound. In the method, under a water-free and oxygen-free condition, aromatic amine and aromatic boric acid react in an organic solvent under the action of alkyl nitrite and palladium, which serve as a catalyst, and an organophosphorus ligand to form the aromatic cross-coupled compound. Compared with the coupling of aromatic diazonium tetrafluoroborate and aromatic boric acid, the method has the advantages that: the reaction of aromatic amine for forming a diazonium salt is accomplished by one step of coupling; the diazonium salt is not needed to be separated; the reaction efficiency is high; and the cost is low. In addition, the method has the characteristics of stable substrate and wide adaptability, has high tolerance and adaptability to functional groups and can be widely used for preparing aromatic cross-coupled compounds. |