http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102234269-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D411-04 |
| filingDate | 2010-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102234269-B |
| titleOfInvention | The industrialized process for preparing of lamivudine |
| abstract | The invention discloses the industrialized process for preparing of lamivudine; the method is with 5-hydroxyl-1; 3-oxathiolane-2-carboxylic acid [(1 ' R; 2 ' S; 5 ' R)-5 '-methyl-2 '-(1-methylethyl) cyclohexyl] ester and acylation reaction obtain acylate; under Louis acid catalysis, the acyl group cytosine(Cyt) of acylate and single silanization or the cytosine(Cyt) schiff bases generation glycosylation of single silanization obtain lamivudine intermediate, restore, deacylated tRNA base or hydrolysis, reduction obtain lamivudine.Raw material of the present invention low price simple and easy to get, easy and simple to handle, production safety, yield is high, and three-waste pollution is few, is applicable to suitability for industrialized production. |
| priorityDate | 2010-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.