| abstract |
The invention provides a preparation method of rosuvastatin calcium. 4-(4-fluorophenyl)-6-isopropyl-2chloropyrimidine-5-carbaldehyde and (3R)-tert-butyldimethylsilyloxy-5-oxo-6-triphenylphosphene Condensation reaction of hexanoic acid ester, followed by removal of the silyl ether protecting group of the hydroxyl group, stereoselective reduction, reaction with 2,2-dimethoxypropane, condensation with N-methylmethanesulfonamide, depropylidene protection, The steps of hydrolyzing the ester group and forming a salt can obtain rosuvastatin calcium. The preparation method of the invention has stable yield, cheap reagents, easy operation, and is beneficial to realize industrialized production. |