http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102212197-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be2c55a9de09e08e3404c0a5a1ae4dc7 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F120-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-685 |
| filingDate | 2011-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d182ef94fad363cedb96cf2d1cb709c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1df49c1167c0c9a873fa7eebadec0881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5f9a1ef0118f8a1c3cd580506df4d82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_347efeb77e83eb2f8591ef4aae76ca6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d6a3703d248390bbbe60ed481079a38 |
| publicationDate | 2011-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102212197-A |
| titleOfInvention | Hyperbranched star polylactic acid-polydimethylaminoethyl methacrylate amphiphilic block copolymer and preparation method thereof |
| abstract | The invention relates to a hyperbranched star polylactic acid-polydimethylaminoethyl methacrylate amphiphilic block copolymer and a preparation method thereof. The preparation method comprises the following steps of: synthesizing a hyperbranched star amphiphilic polymer of which the surface contains a cationic group and a core has a hydrophobic structure by an arm-first method, and synthesizing polydimethylaminoethyl methacrylate containing a terminal alkynyl functional group through atom transfer radical polymerization by taking an esterification reaction product 2-butynol ester bromoisobutyrate of butynol and 2-bromoisobutyryl bromide as an initiator, and cuprous bromide and 1,4,7,10,10-hexamethyltriethylenetetramine as a catalyst system; synthesizing polylactic acid containing a nitrine functional group by a lactide ring-opening polymerization method by taking pentaerythritol tribromide azide as the initiator and stannous octoate as a catalyst, and performing an esterification reaction of an obtained product and trimesoyl chloride to synthesize star polylactic acid azide, namely a star polymer core; and coupling a polydimethylaminoethyl methacrylate arm with the polylactic acid containing the nitrine functional group to obtain the A3 (B3) 3 type star polylactic acid-polydimethylaminoethyl methacrylate amphiphilic block copolymer. The hyperbranched star polymer prepared by the method has high biocompatibility and stability, and has good application prospect in the aspect of antitumor medicine carriers. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104629059-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104629059-B |
| priorityDate | 2011-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467145572 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467591704 |
Total number of triples: 24.