abstract |
The invention relates to a preparation method of a chiral intermediate product for synthesis of statins. The intermediate product is a compound shown as general formula 1, namely (3R)-3-tertbutyldimethylsiloxy-6-dialkoxyphosphono-5-oxo-tertbutyl hexanate, wherein TBS is tertbutyldimethylsiloxy, But is tertbutyl, and R is C1-4 alkyl. |