http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102212040-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dec826fa6437a8006b672f85e461f8fa |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-18 |
| filingDate | 2010-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3453900a0bdce68396ca8907e75b5596 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac985cb41faaccaf30b604c3c910853e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffd0a1c1b9bf0c7f9074bab0174ebae1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07c31f2383a22cdf9c7f22199d5ada1e |
| publicationDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102212040-B |
| titleOfInvention | Novel preparation method for chiral 2-hydroxymethyl morpholine compounds |
| abstract | The invention discloses a novel preparation method for chiral 2-hydroxymethyl morpholine compounds (I), which comprises the following steps: carrying out reaction on chiral glycerin chlorohydrin used as a starting raw material and benzylamine to generate chiral 3-benzylamino-1,2-propanediol (II), acylating the chiral 3-benzylamino-1,2-propanediol (II) to generate a mixture of corresponding chiral N-haloacetyl-N-2,3-dihydroxypropyl-benzylamine (III) and chiral N-haloacetyl-N-(2-hydroxyl-3-haloacetylpropyl)-benzylamine (III'), carrying out cyclization, reduction and hydrogenation to obtain chiral 2-hydroxymethyl morpholine (Ia), and carrying out corresponding protection reaction on amino groups of the 2-hydroxymethyl morpholine (Ia) to generate chiral 2-hydroxymethyl-N-substituted-morpholine (I). The novel preparation method has the advantages of simple and safe used reagents, short steps, high reaction yield of each step, convenient purification of intermediate products and high purity of target products, and is especially suitable for industrial production. |
| priorityDate | 2010-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.