http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102190600-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-59 |
| filingDate | 2010-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e21b86e5d5d16830be8a1c1644dee79b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12f63fdac57d22034d5d47e26869481b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_894414a54afd73675804553eadb5263f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d4a8d64d9757b55adc58cfd956f2bb6 |
| publicationDate | 2015-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102190600-B |
| titleOfInvention | Preparation method of IV intermediate S-diol |
| abstract | The invention provides a method for splitting 4-(4-dimethylamino-1-p-fluorophenyl-1-hydroxyl butyl)-3-(hydroxymethyl) cyanobenzene (II) of racemic to obtain high purity S-diol (I). The preparation method comprises steps of performing crystallization in a mixed solvent containing ethyl acetate and ethanol or a mixed solvent containing ethyl acetate and acetonitrile to obtain S-diol D-(+) di p-methyl-benzoyl-tartaric acid salts. The splitting method provided in the invention has advantages of low cost and high yield; besides, the S-diol that is obtained by splitting has high purity. Therefore, the preparation method of the IV intermediate S-diol is especially suitable for industrialized large-scale production. |
| priorityDate | 2010-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.