http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102188716-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_327804b51d47ff6afc403138b838f3f5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-475 |
| filingDate | 2010-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5a87c70b736786a878dd27b67af78b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84f3d773494a76f0e61dfbdecbff84c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0d94fe1231ebc640825f99638ae34e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2928f96f4f4497a744f013e89fc4fd6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6195112f9f8e5c3497a477b043e24c4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_476a2451caa54f11aadc9c15efc4d834 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d4f455d172546949f9be9a19bde8d8e |
| publicationDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102188716-B |
| titleOfInvention | Macromolecule vinblastine conjugate adopting amino acids or oligopeptides as connexons |
| abstract | The invention relates to a macromolecule vinblastine conjugate adopting amino acids or oligopeptides as connexons. Specifically, the invention relates to a conjugate represented by a formula I, or pharmaceutically-acceptable salts thereof. The conjugate is prepared by conjugating a biocompatible macromolecule and vinblastine through amino acids or oligopeptides, wherein each symbol in the formula I is described in an instruction. The invention further relates to a method for preparing the conjugate or the pharmaceutically-acceptable salts thereof, drug combinations combined through the conjugate and the pharmaceutically-acceptable salts thereof, application in medicine for treating and/or preventing proliferative disease, neoplastic disease or carcinoma disease. According to the present invention, hydroxy group on C-4 of the vinblastine or the hydroxy group on the deacetylated C-4 of derivatives is adopted as a cross-linked group, and is conjugated with the macromolecule through the amino acids or the oligopeptides to obtain an effective conjugate of the vinblastine with novel characteristic. |
| priorityDate | 2010-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 93.