| abstract |
The present invention provides a kind of new compound with excellent NF κ B inhibiting effect,It is following formula (1) compound represented or its salt,In formula,R1 expression hydrogen atom,Low alkyl group,Lower alkoxy or halogen atom; R2 indicates hydroxyl or lower alkoxy; R3 expression hydrogen atom,Low alkyl group or halogen atom; R4 indicates hydrogen atom or lower alkoxy; R5 expression hydrogen atom,Lower alkoxy,Halogen atom,Hydroxyl,With the R6 methylene-dioxy being formed together or different sub- the third two oxygroup being formed together with R6; R6 expression hydrogen atom,Lower alkoxy,With the R5 methylene-dioxy being formed together or different sub- the third two oxygroup being formed together with R5; R7 indicates hydrogen atom or low alkyl group; R8 expression hydrogen atom,Hydroxyl,Amino or lower alkylcarbonyl oxygroup (but not including that R1,R3,R4 and R7 is hydrogen atom,R2 and R8 is hydroxyl,Situations such as R5 and R6 is methoxyl group). |