http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102180906-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_47297b6b1d0a7436517fda591c95e3b4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate | 2011-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a59e40dc571c658aaa90251942f8d93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e57c02168b38599c36afeb700d34ccff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d38fdbc30a33139ca5ee80785f9d2cb |
| publicationDate | 2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102180906-A |
| titleOfInvention | The synthetic method of adefovir dipivoxil compound |
| abstract | The present invention is a kind of synthetic method of adefovir dipivoxil compound, it is characterized in that: in DMF, methyl isobutyl ketone carries out selective imino group protection to adenine 6-primary amino group, then in K 2 CO 3 Condensation with side-chain bis-trifluoroethyl-p-toluenesulfonyloxyethoxymethyl phosphate in the presence of intermediate 9–[bis(trifluoroethoxy)phosphonomethoxyethyl]adenine, Then, 9–[2-(phosphonomethoxy)ethyl]-adenine (ie PMEA) was obtained by hydrolysis with hydrochloric acid in aqueous ethanol solution. PMEA was dissolved in DMF, and amino-protecting agent BSA was added. 2 CO 3 and an appropriate amount of K In the presence of I, react with chloromethyl pivalate to prepare adefovir dipivoxil. The invention prevents the formation of by-products of 6-position isomers through the introduction of protecting groups, reduces the introduction of impurities, has high purity, and improves the yield at the same time, laying the foundation for industrialization. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109053804-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109053804-A |
| priorityDate | 2011-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007013085-A1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467432191 |
Total number of triples: 17.