abstract |
The present invention relates to the method making pluripotent stem cell differentiation.Specifically, the present invention relates to and make pluripotent stem cell differentiation be the method and composition of the cell of expressing definitive entoderm pedigree markers characteristic, described method comprises cultivates described multipotential stem cell in the medium, and described substratum comprises the GDF-8 of q.s to cause described pluripotent stem cell differentiation for expressing the cell of definitive entoderm pedigree markers characteristic. |