abstract |
The present invention provides compounds that are potent antagonists of the CCR1 receptor and possess anti-inflammatory activity in vivo. The compounds are 4-amino-3-imidazolyl-pyrazolo[3,4-d]pyrimidine derivatives, and these compounds can be used in pharmaceutical compositions and methods for treating CCR1-mediated diseases, and can also be used in identifying competitive CCR1 Antagonist was used as a control in experiments. |