| abstract |
Olopatadine can be obtained by a method comprising hydrolyzing a compound of general formula (II), wherein Y is OR 1 , wherein R 1 is C 1 -C 7 alkyl, C 3 -C 7 cycloalkyl, aryl, aryl Alkyl or heterocycle; or Y is NR 2 R 3 , wherein R 2 and R 3 are independently of each other C 1 -C 7 alkyl, aryl, aralkyl, or R 2 and R 3 together with their bonded The nitrogen atoms together form a 3- to 7-membered heterocyclic ring. In a reaction medium containing an organic solvent, in the presence of a base, the compound of the above general formula (II) is obtained by including 6,11-dihydro-11-oxodiphenyl And [b, e] the corresponding ester or amide of oxheptin-2-acetic acid can be obtained by reacting with the appropriate Wittig reagent. |